The 8 Best Ergonomic Mouse | 2021 review Ergonomic4U

The 8 Best Ergonomic Mouse

Table of Contents
ergonomic mouse

When it comes to using Ergonomic Mice, everyone is always looking for the best. After all, we use mice whenever we are at the computer for work and play, and the constant clicking and moving around does get tiring for the hand after a while. You need a good ergonomic mouse that fits your hand and wrist, making sure that you can comfortably use the best ergonomic mouse for a long time. 

There are a lot of specially designed mice out there, and you need to find the best one that works for you. Here are eight of the best ergonomic mice that we’ve found to be some of the best, so take a look and see which one is perfect for your work or gaming computer.

1. Microsoft Sculpt Ergonomic Mouse

Not only is this mouse designed to be ergonomic, but it is also designed to be functional with Windows computers. The ergonomic mouse design is easier for your hand to curl around, and makes the position much more natural. It also comes with a thumb rest on the side, which is something we don’t see in many ergonomic mice. 

It manages to elevate your wrist and hand while in use, and it doesn’t feel obstructive or awkward at all. The ergonomic mouse also comes with the MicrosofTrack technology to give you unparalleled control and feedback on any surface. No more fiddling around and hoping that the optical sensor is responsive on your desk. Instead, you can drag your ergonomic mouse on any surface and get your mouse where you need it to go on your screen.

Finally, it comes with a big blue windows start button, easily pressed with a finger while you are working. If you find yourself constantly needing to navigate to the lower right of the screen or tapping the windows home key and breaking your typing flow, then this mouse makes that process much easier.


  • Microsoftrack tech let’s you use your mouse anywhere
  • Easy access to the Start Menu
  • Has a Thumb Scoop and simple scroll wheel


2. Anker 2.4G Wireless Ergonomic Optical Mouse

This might be one of the most uniquely shaped MX vertical mice on the planet. The whole point of an ergonomic mouse is to connect with your hand shape so the ergonomic mouse is comfortable to hold, and this mouse takes that literally. Instead of being a simple mouse that you place your hand over, the vertical proportions of this mouse mean that you have to put your hand around it. 

The First Mx Vertical Mouse

This vertical ergonomic mouse was designed to take advantage of our natural ‘handshake’ wrist and arm movement to keep the strain off, and it works! The best ergonomic mouse also comes with optical tracking tech to ensure the sensitivity and responsiveness aren’t taken away. 

Of course, it comes with extra buttons to provide convenience when working or gaming, allowing you to cycle through items with ease. It also has a great scroll wheel that is easily accessible. Finally, the vertical mouse is even smart enough to enter power-saving mode whenever you leave it idle, keeping its battery safe.


  • Very unique design
  • Comes in three different resolutions
  • Encourages a neutral position of the hand.


3. Logitech M570 Wireless Trackball Mouse

What’s more frustrating than wrestling with your own Logitech MX master mouse? There are always these occasions where your mouse goes AWOL and sends the cursor flying across the screen even when you don’t move it or touch the scroll wheel. This mouse from Logitech comes with a trackball, allowing you to manipulate the cursor with your thumb without moving your mouse at all. 

You might be thinking that a trackball wireless mouse is weird to use, but once you get your hand used to moving your cursor on the natural thumb rest, you might be wondering how you ever used a normal wireless mouse!

The trackball mouse also has 18 months of battery life and comes with a very handy battery tracking chip so you always see the process. No matter where you are using this trackball mouse, you gain the benefits of an ergonomic mouse and fluid tracking control. It doesn’t matter if you are working from a desk, a bed, or anywhere else. You’ll have the perfect MX master mouse to get all your work done.


  • A Long Battery Life
  • Sculpted Ergonomic Shape
  • Precise Cursor Control

4. J-Tech Digital Ergonomic Vertical Mouse

This wireless vertical mouse isn’t just ergonomic, but it also comes with all sorts of features to make sure that you are getting the best bang for your buck. The J-tech computer mouse design follows the ‘handshake positioning’ principle to reduce strain on your hands, along with two buttons that can be accessed by the thumb.

The wireless vertical ergonomic mouse also comes with a removable palm rest, which is something we don’t see too much of in the wireless mouse industry. The anti-sweat palm rest helps to rest your palm comfortably while you maneuver the vertical mouse across the top of the table. It also comes with four different levels of responsiveness for your computer and free lifetime support.


  • Vertical Design that is different from a traditional mouse
  • Adjustable DPI to four levels
  • Removable Palm Rest


5. Jelly Comb Advanced MX Vertical Wireless Bluetooth Mouse

Not only does this wireless vertical ergonomic mouse come with a vertical design to take advantage of the ergonomic handshake movement, but it also has compatibility with several devices, and the ability to service two devices at once. It has dual connection modes, and this is something we don’t see in a lot of mice, but if you have one computer connected with your USB receiver and a second computer connected with your Bluetooth, this vertical mouse can swap between them with the tap of a button.

This is a game-changer for those who like to be productive on two screens but hate having to go back and forth to two sets of wireless mice and wireless keyboards. It’s perfect for the two computer office worker, and comes with all the other benefits you would expect from a wireless mouse.


  • Adjustable DPI and Silent Click
  • Can Service Two Devices at the same time
  • Vertical Ergonomic Mouse design


6. VicTsing Wireless Mouse

This wireless mouse doesn’t have a fancy shape like all of the other mice on this list, but it does have an ergonomic shape and several other features. It has a tested and streamlined arc and finger rest to ensure you are comfortable even with prolonged use. Plus, even a fool could set it up as it has a simple ‘plug and play’ method. Just plug it into your laptop and it should connect!

The Logitech MX ergo mouse comes with 5 levels of DPI, two side buttons, and advanced tracking technology to make sure that you can do everything you need to do. All while using this mouse comfortably and to its fullest capabilities for your computer. 


  • Comes with 15 months of battery life
  • Cordless and wireless
  • Tested Ergonomic Design


7. Reddragon M601 RGB Gaming Mouse

If you happen to be a gamer looking for one of the best ergonomic mice around, then this is the best one for you. This durable and ergonomic gaming mouse comes with five levels of DPI, culminating in 7200 DPI. That means more accuracy for you and greater longevity for the optical sensor. You also have 6 buttons that can be mapped to any command and can be assigned to one of three memory profiles, making it very easy to swap your loadout depending on what you are playing. 

The mouse is designed to solely fit your hand and reduce both muscle and click fatigue while being compatible with a wide array of devices. Plus, it even comes with 11 lighting effects to further improve its customization. No matter what, you should be able to find a use for this mouse, regardless of the game you play on your computer!


  • 6 programmable customizable buttons
  • Ergonomic Design to prevent click fatigue
  • Very responsive sensor

8.DELUX Wired Ergonomic Vertical Mouse

This Logitech MX vertical mouse uses the same vertical design that we’ve seen on this list before, reducing both your arm discomfort and preventing hand cramps. It also comes with a removable wrist pad, perfect for resting your wrist after a long gaming session. The DELUX mouse also comes with 5 levels of DPI, which can be easily shifted with the tap of a button.

Finally, all DELUX Logitech MX vertical products come with a year’s warranty and lifetime tech support, making sure that you are going to be able to use this mouse for a long time to come. Whether you are using this 6 button mouse to make changes to your work PowerPoint or beat the final boss in gaming, it is going to work for you.


  • Designed to reduce pressure on your hand and wrist
  • 5 options for DPI
  • Comes with removable wrist rest


Final Thoughts On The Best Ergonomic Mouse

Only you can determine the type of ergonomic mouse that is right for you, but you should be looking for some good mice that are designed to keep your hand and wrist comfortable.
That’s the most important part, and everything else is secondary.

Spread The Word To Your Friends
Table of Contents
Products Of The Month